Trinidad was the flagship of Ferdinand Magellan's voyage of circumnavigation. Unlike Elcano's Victoria, which returned to Spain sailing across the Indian Ocean, Trinidad tried and failed to sail east across the Pacific to New Spain or modern-day Mexico. Trinidad was a nao (ship) of 100 tons (or 110 tons, Morrison has both) with square sails on the fore and main masts and a lateen mizzen. Its original crew was 61. After Magellan's death and the burning of the Concepcion, Victoria and Trinidad (the San Antonio and the Santiago being lost earlier) reached Tidore on 8 November 1521. In mid-December both ships attempted to depart loaded with cloves, but Trinidad almost immediately began to leak badly. Inspection showed that the problem was serious. It was agreed that Victoria would leave for Spain and Trinidad would remain for repairs.

On 6 April 1522, Trinidad left Tidore loaded with 50 tons of cloves. Her commander was Gonzalo Gomez de Espinosa, Magellan's alguacil (master-at-arms), a good soldier, but no sailor. After ten days Trinidad put in at one of the Marianas, where three men deserted, and then headed northeast. Espinosa was apparently trying to reach the Westerlies, but did not find them, probably because of the summer monsoon. He reached 42 or 43 degrees north in increasingly bad weather. Scurvy set in, ultimately killing 30 men and leaving only 20 to sail the ship. Five months after leaving, he turned back and two months later reached the Moluccas.

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