Kennedy met his future wife, Jacqueline Lee "Jackie" Bouvier (1929–1994), when he was a congressman. Charles L. Bartlett, a journalist, introduced the pair at a dinner party. They were married a year after he was elected senator, on September 12, 1953.

After suffering a miscarriage in 1955 and a stillbirth in 1956 (their daughter Arabella), their daughter Caroline was born in 1957 and is the only surviving member of JFK's immediate family.

John Fitzgerald Kennedy Jr., nicknamed "John-John" by the press as a child, was born in late November 1960, 17 days after his father was elected. John Jr., a graduate of Brown University, died in 1999 when the small plane he was piloting crashed en route to Martha's Vineyard.

In 1963, months before JFK's assassination, Jackie gave birth to a son, Patrick. However, he died after 2 days due to complications from birth.

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