A quire of paper is a measure of paper quantity. The usual meaning is 25 sheets of the same size and quality:  1⁄20 of a ream of 500 sheets. Quires of 25 sheets are often used for machine-made paper, while quires of 24 sheets are often used for handmade or specialized paper of 480-sheet reams. (As an old UK and US measure, in some sources, a quire was originally 24 sheets.) Quires of 15, 18 or 20 sheets have also been used, depending on the type of paper.

In the Middle Ages, a quire (also called a "gathering") was most often formed of 4 folded sheets of vellum or parchment, i.e. 8 leaves, 16 sides. The term "quaternion" designates such a quire. A quire made of a single folded sheet (i.e. 2 leaves, 4 sides) is a "bifolium" (plural "bifolia"); a "binion" is a quire of two sheets (i.e. 4 leaves, 8 sides); and a "quinion" is five sheets (10 leaves, 20 sides).

Formerly, when paper was packed at the paper mill, the top and bottom quires were made up of slightly damaged sheets ("outsides") to protect the good quires ("insides"). These outside quires were known as "cassie quires" or "cording quires" and had only 20 sheets to the quire. The printer William Caslon in a book published in 1770 mentions both 24- and 25-sheet quires. An 1826 French manual on typography complained that cording quires (usually containing some salvageable paper) from the Netherlands barely contained a single good sheet.

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