The Great Slave Lake is the second-largest lake in the Northwest Territories of Canada (after Great Bear Lake), the deepest lake in North America at 614 metres (336 fathoms; 2,014 ft), and the tenth-largest lake in the world. It is 469 km (291 mi) long and 20 to 203 km (12 to 126 mi) wide. It covers an area of 27,200 km2 (10,502 sq mi) in the southern part of the territory. Its given volume ranges from 1,070 km3 (260 cu mi) to 1,580 km3 (380 cu mi) and up to 2,088 km3 (501 cu mi).

The lake shares its name with the Slavey First Nations. Towns situated on the lake include Yellowknife, Hay River, Behchoko, Fort Resolution, Lutselk'e, Hay River Reserve, Dettah, and N'Dilo. The only community in the East Arm is Lutselk'e, a hamlet of about 350 people, largely Chipewyan Aboriginals of the Dene Nation and the now abandoned winter camp/Hudson's Bay Company post, Fort Reliance. Along the south shore, east of Hay River is the abandoned Pine Point Mine and the company town of Pine Point.

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