The film "One True Thing", a 1998 big drama, was directed by Carl Franklin. It tells the story of a woman in her 20s; she is forced to put her life on hold to care for her mother, who is dying of cancer. The script was adapted by Karen Croner from the novel "One True Thing" by Anna Quindlen, with the story being based on Quindlen's own struggle with the death of her mother, Prudence Pantano Quindlen, from ovarian cancer in 1972.

This film stars Meryl Streep, Renée Zellweger, William Hurt, and Tom Everett Scott. Bette Midler sings the lead song, "My One True Friend", over the end credits. The track was first released on Midler's 1998 album "Bathhouse Betty". The film was shot in Morristown, New Jersey and Maplewood, New Jersey, as well as at the campus of Princeton University.

The film's plot is focused on Kate (Streep), the undervalued matriarch of the Gulden family; she has been diagnosed with cancer. At the request of her father (Hurt), the daughter and journalist Ellen (Zellweger) returns from New York City to care for her mother. During the time Kate spends with her parents, she discovers secrets that she was never privy to in her childhood. Though Ellen has always idolized her father, she learns that her mother has had a much more difficult life than she knew.

The film received favorable reviews from critics, with Streep being the subject of acclaim for bringing warmth and natural energy to her role. She was nominated for the Oscar Award for Best Actress.

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