Captain Kathryn Janeway of the USS Voyager often enjoyed visiting the holographic figure of Leonardo da Vinci on the ship's holodeck. He became a personal adviser to her. She would visit him and found that the holodeck provided a haven during times of stress. One example concerns the time when Captain Janeway was unsure of how to approach an alliance with the Borg. Leonardo counseled Janeway. He told her that everything is a matter of interpretation and perspective and that she could turn the situation to her advantage. It was just a matter of being creative in devising a solution.

Leonardo and Janeway developed an unconventional friendship. It caused them to take part in an unsuccessful attempted to fly in a glider that they constructed. It sent them crashing into a river. This led to the holographic Leonardo having a crisis of purpose and leaving many of his historic works unfinished.

'Catarina', as he called her, often liked to call him the honorific 'Maestro', and frequently employed occasional words of Italian in her conversations with him.

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