Saint Apollonia was one of a group of virgin martyrs who suffered in Alexandria during a local uprising against the Christians prior to the persecution of Decius. According to legend, her torture included having all of her teeth violently pulled out or shattered. For this reason, she is popularly regarded as the patroness of dentistry and those suffering from toothache or other dental problems. French court painter Jehan Fouquet painted the scene of St. Apollonia's torture in The Martyrdom of St. Apollonia.

The Eastern Orthodox and Roman Catholic Churches celebrate the feast day of St. Apollonia on February 9, and she is popularly invoked against the toothache because of the torments she had to endure. She is represented in art with pincers in which a tooth is held. In a late 14th-century illumination from a French manuscript, the tooth in her pincers glows from within, like a lightbulb.

There was a church dedicated to her in Rome, near the Basilica di Santa Maria in Trastevere, but it no longer exists. Only its little square, the Piazza Sant' Apollonia remains. One of the principal train stations of Lisbon is also named for this saint. There is a statue of Saint Apollonia in the church at Locronan, France. The island of Mauritius was originally named Santa Apolóniain her honor in 1507 by Portuguese navigators. Her image is the side support of the arms of the British Dental Association.

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