Of Mice and Men is a 1992 American period drama film based on John Steinbeck's 1936 novella of the same name. Directed and produced by Gary Sinise, the film features Gary Sinise as George Milton, alongside John Malkovich as Lennie Small, with Casey Siemaszko as Curley, John Terry as Slim, Ray Walston as Candy, Joe Morton as Crooks, and Sherilyn Fenn as Curley's wife.

Horton Foote adapted the story for film. Its plot centers on George and the intellectually disabled Lennie, two farm workers who travel together and dream of one day owning their own land. The film explores themes of discrimination, loneliness, and the American Dream.

Of Mice and Men is a novella written by John Steinbeck. Published in 1937, it tells the story of George Milton and Lennie Small, two displaced migrant ranch workers, who move from place to place in California in search of new job opportunities during the Great Depression in the United States.

Steinbeck based the novella on his own experiences working alongside migrant farmworkers as a teenager in the 1910s (before the arrival of the Okies that he would describe in The Grapes of Wrath). The title is taken from Robert Burns' poem "To a Mouse", which reads: "The best-laid schemes o' mice an' men / Gang aft agley". (The best-laid schemes of mice and men / Often go awry.)

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