The 5 Fs as risk group in gall bladder stones are Female, Forty, Fertile, Fatty and what?

There was an explanation behind the 5 F’s mnemonic of gallstone disease: The incidence of gallstones had been thought to be more common in Females over Forty as they were reaching perimenopause. Women who were Fertile, meaning that they had one or more children, were thought to be at higher risk due to higher estrogen levels and the association of gallstones with pregnancy. Fair was part of the 5 F’s because it was believed that gallstones were more common in Caucasian women, and Fat was included because being “overweight” or “obese” was linked to increased levels of cholesterol that could cause gallstones.

Gallstones (commonly misspelled gall stones or gall stone) are solid particles that form from bile cholesterol and bilirubin in the gallbladder.

The gallbladder is a small pear-shaped saclike organ in the upper right part of the abdomen. It is located under the liver, just below the front rib cage on the right side. The gallbladder is part of the biliary system, which includes the liver and the pancreas. The biliary system, among other functions, transports bile and digestive enzymes.