Mesopotamia ("land of rivers") was a historical region situated within the Tigris–Euphrates river system, in modern days roughly corresponding to most of Iraq plus Kuwait, the eastern parts of Syria, Southeastern Turkey, and regions along the Turkish-Syrian and Iran–Iraq borders.

Mesopotamia is the site of the earliest developments of the Neolithic Revolution from around 10,000 BC. It has been identified as having "inspired some of the most important developments in human history including the invention of the wheel, the planting of the first cereal crops and the development of cursive script, mathematics, astronomy and agriculture."

Mesopotamian mathematics and science was based on a sexagesimal (base 60) numeral system. This is the source of the 60-minute hour, the 24-hour day, and the 360-degree circle. The Sumerian calendar was based on the seven-day week. This form of mathematics was instrumental in early map-making. The Babylonians also had theorems on how to measure the area of several shapes and solids. They measured the circumference of a circle as three times the diameter and the area as one-twelfth the square of the circumference, which would be correct if pi were fixed at 3.

Mesopotamian people invented many technologies including metal and copper-working, glass and lamp making, textile weaving, flood control, water storage, and irrigation. They were also one of the first Bronze Age societies in the world.

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