Calpurnia was the third and last wife of Julius Caesar. Born in 75 BC, she was the daughter of Lucius Calpurnius Piso Caesoninus, a Roman consul in 58 BC.

Calpurnia married Caesar in late 59 BC. Historians during her life described her as a humble, often shy woman. No children resulted from her union with Caesar. Caesar's daughter, Julia, was likely older than Calpurnia, her stepmother. And, in fact, Julia married Gnaeus Pompeius Magnus around the same time that Caesar and Calpurnia got married.

Following Caesar's death in 44 BC, Calpurnia delivered all Caesar's personal papers, including his will and notes, and his most precious possessions to the consul Marcus Antonius (Mark Antony), one of Caesar's most trusted allies. Specifically, because Calpurnia was Caesar's widow, she had papers stating that Mark Antony was, by will of Caesar, to be named his legal heir and commander of the Caesarian troops. Ultimately, after performing her duties of a widow, Calpurnia never remarried.

According to a tradition reported in some ancient sources, Calpurnia had a premonition about her husband's murder and endeavored in vain to warn him. Unaware that praetor Decimus Junius Brutus Albinus was one of the conspirators against her husband, she asked him to send word to the Senate that Caesar was ill and unable to attend. Caesar however rejected this plan, and Brutus escorted him into the hands of his enemies.

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