The 1933 Major League Baseball All-Star Game was the first edition of the All-Star Game known as the "Midsummer Classic". This was the first official playing of the midseason exhibition baseball game between Major League Baseball's (MLB's) National League (NL) and American (AL) All-Star teams. The game was held on July 6, 1933, at Comiskey Park in Chicago, Illinois, the home of the AL's Chicago White Sox. The game resulted in the AL defeating the NL 4–2, in two hours and five minutes.

The first MLB All-Star game (unofficial all-star game called the Addie Joss Benefit Game) was held on July 24, 1911, in Cleveland at Cleveland League Park (League Park, 1891–1946), the American League All-Stars versus the Cleveland Naps (1903–1915). The AL All-Stars won 5-3.

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