Avantame is marketed as 20,000 times sweeter than sugar and has the highest sweetness known. It is a non-calorie sweetener from Japan's Ajinomoto Company. The U.S. Food and Drug Administration (FDA) has approved 'advantame' for general use in foods and beverages except meat and poultry as a food additive.

It is synthesized from isovanillin and aspartame. The E-number for 'advantame' is E 969. Its chemical formula is C24H30N207. Advantame is classified as generally recognized as safe by the Flavor and Extract Manufacturers Association for use in dairy, frozen desserts, beverages, and chewing gum. The Center for Science in the Public Interest, Washington, ranks 'advantame' as safe.

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