A diesel locomotive is a type of railway locomotive in which the prime mover is a diesel engine. Several types of diesel locomotives have been developed, differing mainly in the means by which mechanical power is conveyed to the driving wheels.

In 1906, Rudolf Diesel, Adolf Klose and the steam and diesel engine manufacturer Gebrüder Sulzer founded Diesel-Sulzer-Klose GmbH to manufacture diesel-powered locomotives.

Sulzer had been manufacturing Diesel engines since 1898. The Prussian State Railways ordered a diesel locomotive from the company in 1909, and after test runs between Winterthur and Romanshorn the diesel–mechanical locomotive was delivered in Berlin in September 1912.

The world's first diesel-powered locomotive was operated in the summer of 1912 on the Winterthur–Romanshorn railroad in Switzerland, but was not a commercial success. During further test runs in 1913 several problems were found. After the First World War broke out in 1914, all further trials were stopped. The locomotive weight was 95 tonnes and the power was 883 kW with a maximum speed of 100 km/h. Small numbers of prototype diesel locomotives were produced in a number of countries through the mid-1920s.

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