Gregory House, M.D., commonly referred to by his surname House, is the title character of the American medical drama series House. Created by David Shore and portrayed by English actor Hugh Laurie, he leads a team of diagnosticians as the Head of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital in Princeton, New Jersey (based on the real-life Yale–New Haven Hospital in New Haven, Connecticut).

Similarities between House and the famous fictional detective Sherlock Holmes appear throughout the series. Shore explained that he was always a Sherlock Holmes fan, and found the character's traits of indifference to his clients unique. The resemblance is evident in various elements of the series' plot, such as House's reliance on psychology to solve a case, his reluctance to accept cases he does not find interesting and House's home address, 221B Baker Street, which is the same as Holmes'.

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