The Arno is a river in the Tuscany region of Italy. It is the most important river of central Italy after the Tiber. It crosses Florence, where it passes below the Ponte Vecchio and the Santa Trinita bridge (built by Bartolomeo Ammannati but inspired by Michelangelo). The river flooded this city regularly in historical times, most recently in 1966, with 4,500 cubic metres per second (160,000 cu ft/s) after rainfall of 437.2 millimetres (17.21 in) in Badia Agnano and 190 millimetres (7.5 in) in Florence, in only 24 hours.

The river originates on Monte Falterona in the Casentino area of the Apennines, and initially takes a southward curve. The river turns to the west near Arezzo passing through Florence, Empoli and Pisa, flowing into the Tyrrhenian Sea at Marina di Pisa. With a length of 241 kilometres (150 mi), it is the largest river in the region.

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