Which of these creatures regularly preys on skunks?

Most predators with a sense of smell need only one encounter with a skunk before learning to keep their distance; and because skunks sport distinctive black-and-white coats, they're easily recognizable to predators. Any would-be attacker recognizing a skunk knows to stay away or will hunt the animal only as a last resort. As a mostly nocturnal animal, the skunk uses his coloring as camouflage in the dark, but his coat makes it unmistakably clear to those who do find him that he is, in fact, a skunk.

Some ground carnivores prey on skunks. While the exact number of species that prey on skunks is unknown, red foxes, cougars, coyotes and domestic dogs are among them. These animals tend not to prefer skunk, though, because it is difficult to successfully attack and kill one without being soaked in its pungent natural spray. Most such predators will prey on skunks only if their other options are limited or nonexistent.

Unfortunately for the skunk, his most notorious and effective defense mechanism is powerless against predators striking from the sky. Species like the great horned owl and the red-tailed hawk prey on skunks from above. While some birds of prey have a sense of smell, these and others have little to none, rendering them effectively invulnerable to the spray that keeps most other predators at bay.