The nickname “Slowhand” was not, as is commonly thought, given to Clapton due to playing the guitar slowly. Rather, it was given to him because of audiences giving him a slow hand clap when he would replace guitar strings on stage. When most guitar players break a string on stage, a roady will typically bring them another guitar and fix the string on the old one off-stage. Clapton, on the other hand, had a practice of standing on stage and replacing and tuning the string in front of the audience. While he was doing this during one particular performance, the audience gave him a slow clap or a “slow hand” until he had fixed it and was ready to play again. This slow-clap ultimately became a common thing with Clapton while with the Yardbirds because whenever he'd break a string during a performance, the audience would give him a slow clap until he was finished replacing it. According to Clapton, Yardbirds manager Georgia Gomelsky gave him the nickname.

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