Which South American capital city is called 'Mother of Cities'?

Asunción, known as the "Mother of Cities," is one of the oldest cities in South America founded in 1537; It was from there that the colonial expeditions departed to found other cities, including the second foundation of Buenos Aires, Villarrica, Corrientes, Santa Fe and Santa Cruz de la Sierra.

Asunción (full name: Nuestra Señora Santa María de la Asunción), a city of 512,112 (1,858,000 in its metropolitan area), is the capital of Paraguay, home of the national government, principal port, and chief industrial and cultural center of the country. It dominates social, cultural, and economic trends in the nation.

The name of the city, Asunción, refers to the Assumption of Mary; the full name means Our Lady, Holy Mary of the Assumption. It was given this name when a stockade was completed there on the Feast of the Assumption (August 15) in 1537.