The Battle of Ponza (1552) was a naval battle that occurred near the Italian island of Ponza. The battle was fought between a Franco-Ottoman fleet under Dragut and a Genoese fleet commanded by Andrea Doria. The Genoese were defeated and lost seven galleys captured. The battle made it easier for the Ottoman fleet to raid the coasts of Sicily, Sardinia and Italy for the next three years.

The Ottoman fleet consisted of 100 galleys which had been sent to the Western Mediterranean when Henry II entered in conflict with Charles V in the Italian War of 1551-59. The fleet was accompanied by three French galleys under the French ambassador Gabriel de Luetz d'Aramon, who accompanied the Ottomans from Istambul in their raids along the coast of Calabria in Southern Italy, capturing the city of Reggio.

The Genoese fleet consisted of 40 galleys under the command of Andrea Doria. Twenty of the galleys in the Genoese fleet belonged personally to Doria, six to an Antonio Doria and two to the House of Grimaldi of Monaco.

After the battle, the Ottoman fleet wintered in Chios, where it was joined by the French fleet of Baron de la Garde, ready for major naval operations the following year, including the, later failed, Invasion of Corsica in 1553. In 1560 the nephew of Doria, Giovanni Andrea Doria, led another attempt to thwart Dragut at the Battle of Djerba in but was defeated and Dragut continued his raiding of the Northern Mediterranean shores until his death five years later.

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