Which was the first manned spaceflight mission to reach the Moon?

Apollo 8, the second manned spaceflight mission flown in the United States Apollo space program, was launched on December 21, 1968, and became the first manned spacecraft to leave low Earth orbit, reach the Moon, orbit it, and return. The three-astronaut crew were Frank Borman, James Lovell, and William Anders and they were the first humans to fly to the Moon, to witness and photograph an Earthrise, and to escape the gravity of a celestial body. Apollo 8 was the third flight and the first crewed launch of the Saturn V rocket and was the first human spaceflight from the Kennedy Space Center, located adjacent to Cape Canaveral Air Force Station in Florida.

Apollo 8 took 68 hours (almost three days) to travel the distance to the Moon. The crew orbited the Moon ten times over the course of twenty hours, during which they made a Christmas Eve television broadcast in which they read the first ten verses from the Book of Genesis. At the time, the broadcast was the most watched TV program ever. Apollo 8's successful mission paved the way for Apollo 11 to fulfill U.S. president John F. Kennedy's goal of landing a man on the Moon before the end of the 1960s. The Apollo 8 astronauts returned to Earth on December 27, 1968, when their spacecraft splashed down in the northern Pacific Ocean. The crew members were named Time magazine's "Men of the Year" for 1968 upon their return.