Henry Clay Sr. was the first person known in U.S. history to be called "The Great Compromiser". He brokered important agreements during the Nullification Crisis and on the slavery issue. As part of the "Great Triumvirate" or "Immortal Trio," along with his colleagues Daniel Webster and John C. Calhoun, he was instrumental in formulating the Missouri Compromise of 1820, the Compromise Tariff of 1833, and the Compromise of 1850 to ease sectional tensions.

He was viewed as the primary representative of Western interests in this group, and was given the names "Harry of the West" and "The Western Star." As a plantation owner, Clay held slaves during his lifetime, but freed them in his will.

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