"The Boy in the Plastic Bubble" is a 1976 American made-for-television drama film inspired by the lives of David Vetter and Ted DeVita, who lacked effective immune systems. It stars John Travolta, Glynnis O'Connor, Diana Hyland, Robert Reed, Ralph Bellamy & P.J. Soles. It was written by Douglas Day Stewart, executive produced by Aaron Spelling and Leonard Goldberg (who, at the time, produced Starsky and Hutch and Charlie's Angels), and directed by Randal Kleiser, who would work with Travolta again in Grease shortly after. The original music score was composed by Mark Snow. The theme song "What Would They Say" was written and sung by Paul Williams. William Howard Taft High School in Woodland Hills was used for filming.

The "Bubble Boy" who inspired this film, David Vetter, questioned the film's depiction of how sterile Tod's use of the spacesuit was. Vetter scoffed at the idea that Travolta's character could simply wear the space suit back into the isolator without contaminating the bubble. The film was nominated for four Emmy Awards, winning one posthumously for Hyland. Travolta's positive experiences on the film led him to request Kleiser as director when he was cast as the lead in the 1978 film Grease; Kelly Ward also appeared in that film.

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