With the dawn of the Open Era in 1968, professional players were once again allowed to compete in Grand Slam events. Laver became Wimbledon's first Open Era champion in 1968, beating the best amateur, American Arthur Ashe, in a semifinal and fellow-Australian Tony Roche in the final, both in straight sets.

Laver was also the runner-up to Ken Rosewall in the first French Open. In this first "open" year, there were only eight open events besides Wimbledon and the French Open, where professionals, registered players, and amateurs could compete against each other. The professionals mainly played their own circuit, with two groups – National Tennis League (NTL) and World Championships Tennis (WCT) – operating. Laver was ranked No. 1 universally, winning the US Professional Championships on grass and the French Pro Championship on clay (both over John Newcombe).

Laver also won the last big open event of the year, the Pacific Southwest in Los Angeles on hard courts. Ashe regarded Laver's 4–6, 6–0, 6–0 final win over Ken Rosewall as one of his finest performances. Laver's post-match comment was, "This is the kind of match you always dream about. The kind you play at night in your sleep."

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